Thesis

Sulfur chemistry : thiolates, disulfides, thioethers and thiones

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Awarding institution
  • University of Strathclyde
Date of award
  • 2015
Thesis identifier
  • T16681
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Abstract
  • The thesis brings together my efforts in research over the past 35 years. The work has been collected together under a number of themes and not in chronological order. An overview and full list of publications are given in Chapter 1.Research commenced with a study of the nitroprusside anion as a vasodilator (Chapter 2). Although nitric oxide never became a central theme of my research it has been incorporated it my work on occasions and these efforts are brought togetherin this section. These studies, however, did highlight the importance of sulfhydryl compounds which did become a central theme of my research. Thus, Chapter 3 details studies on the bio-organometallic chemistry of arsenic and the importance of thiolates in arsenic reduction and the formation of thioarsinites. Chapter 4 changesemphasis focusing on the use of small molecule (glutathione, N-acetylcysteine) and protein sulfhydryl groups as a redox buffers in clinical science. Studies detailing the ability of sulfhydryl functions to bind and modify therapeutic complexes are also discussed.A re-alignment in my research lead to three new areas of research. Chapter 5 discusses efforts to design a redox sensitive MRI contrast agent using thioether macrocycles. This continues the theme ofoxidative stress in disease. The design, synthesis and reactivity of soft scorpionates ligands (thione donors) is discussed in Chapter 6. This work marks a return to mainstream coordination chemistry. The combination of the topics discussed in Chapter 5 and 6 generated a final research theme on multi metallic complexes.The connections between these topics is discussed which in turn explains how it is possible to drift across themes (anaesthesia, microbiology, rheumatology) while engaging in chemistry from all areas of the periodic table.
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