Thesis
Development of a portable adsorbent technology for the treatment of systemic inflammation in a range of clinical environments
- Creator
- Rights statement
- Awarding institution
- University of Strathclyde
- Date of award
- 2012
- Thesis identifier
- T13158
- Qualification Level
- Qualification Name
- Department, School or Faculty
- Abstract
- Background: Systemic inflammation, whether it is the result of infectious or traumatic insult, typically has a high mortality rate, often with the exact cause of death remaining elusive. Observations in recent years have led to specific definitions for infectious and non-infectious systemic inflammation, as well as a greater understanding of the pathophysiology on the molecular and cellular levels. Despite the multitude of insults that can lead to systemic inflammation, the symptoms and pathophysiology of the condition remain similar, and the development of pharmaceutical or technological treatment typically focuses on the targeting of the intrinsic molecular mechanisms associated with the progression of the condition. Objectives: In this research project, the use of an extracorporeal adsorbent technology is proposed to remove inflammatory mediators from circulating blood. The main objective of this study is to develop a miniaturised portable adsorbent technology. This can be achieved by completing a series of smaller objectives, these include; The development of a miniaturised portable blood pump. The immobilisation of adsorbent microbeads in a manner which allows continuous blood flow across the beads without causing an embolism risk or high resistance to flow. The effective integration of these extracorporeal technologies in a manner that leads to effective cytokine removal from circulating blood to a clinically relevant degree with a technology that lends itself to a broad range of applications. Approach: Designs were developed for a series of blood pump concepts, some of which were modelled computationally; others were developed into prototypes and tested in the laboratory. Subsequent to the development of these concepts, laboratory testing of the adsorbent material was performed to further inform the design of the overall device. Following this, a clinical study was undertaken in which the device was deployed in one of the situations in which we envisage its use, post cardiopulmonary bypass cytokine filtration. vi Outcomes: Upon completion of this research project, multiple concepts had been proposed and explored for the development of a portable integrated cytokine adsorption technology. Many remained in a conceptual phase, as a result of various limiting factors. Others were developed into prototypes, and integration was achieved with relatively little complication. In the testing of the adsorbent device, a series of complications was discovered in relation to the use of interleukin proteins in vitro. Limitations were found in using these proteins in the laboratory setting, which were critical to this research as they have a significant impact on the assumption of cytokine stability in control solutions. The subsequent testing of the device in near-clinical studies, reinforced these findings, but also showed the considerable ability of the cytokine adsorption device to perform well under these conditions. Through this research, we were able to develop a truly portable cytokine adsorption technology and confirm its efficacy under clinical conditions.
- Resource Type
- DOI
- Date Created
- 2012
- Former identifier
- 947381
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