Thesis
Biomechanical biomarkers of cancer
- Creator
- Rights statement
- Awarding institution
- University of Strathclyde
- Date of award
- 2015
- Thesis identifier
- T14207
- Person Identifier (Local)
- 201450764
- Qualification Level
- Qualification Name
- Department, School or Faculty
- Abstract
- Cancer has become one of the most common diseases, its treatment and diagnosis is of utmost importance. Because of this, it is important to find methods of diagnosing this disease at the earliest possible stage. This aim of this project is to assess the use of mechanical properties of cancerous cells for a new diagnosis method that would be faster, more reliable and would be able to identify the disease at a very early stage. A model of cancer cells embedded in collagen hydrogel was created using finite element software and cancer cells were modelled using various different properties by varying parameters such as the size, depth, Young's Modulus, and hydraulic permeability. The effect of these parameters on the response was assessed by applying a ramp-hold loading and a sinusoidal load to the model, and then analysing the force and phase responses. It was found that very small cancers cannot be diagnosed through this method. Diagnosis of more developed cancers having higher stiffness and/or lower permeability can be achieved by analysing the response of the system; however, it was noted that at high values of Young's Modulus, the hydraulic permeability did not affect the response by much, whilst at low values of Young's Modulus, the effects of hydraulic permeability were more visible in the response. It was also found out that the cancer cells should be placed as far as possible from the moving surface and that higher frequencies (when using a sinusoidal load) tend to give better results in terms of force response.
- Resource Type
- DOI
- Date Created
- 2015
- Former identifier
- 1247535
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