Thesis

Investigating the effects of Extra-Corporeal Irradiation on the mechanical properties of bone

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Awarding institution
  • University of Strathclyde
Date of award
  • 2012
Thesis identifier
  • T13240
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Abstract
  • This project investigated the influence of Extra-Corporeal Irradiation on the elastic and viscoelastic properties of bone. Bone specimens were extracted from mature cattle and subdivided into thirteen groups, including a control group with twelve groups exposed to increasing levels of irradiation. The specimens, once irradiated, underwent mechanical testing in saline at 37°C. Mechanical Properties were calculated by experimental means which included Young's Modulus, Poisson's Ratio, Dissipation Factor and Dynamic Modulus. These were all obtained for the comparison to the control group to the irradiated specimens. From the results calculated in the project, it was shown that the overall effect of increasing irradiation doses up to 300Gy seems to present negligible change, albeit negative, in the behavior of bone. However, the increase in Poisson's Ratio post ECI treatment was statistically significant in relation to the dose administered to the specimen through ANOVA testing. Therefore, it is concluded that the effect that high levels of Extra-Corporeal Irradiation (300Gy) is minute, and should be administered to reduce the chances of possible recurrence of cancer.
Resource Type
DOI
Date Created
  • 2012
Former identifier
  • 947996

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