Thesis
Remote controlled drug release in drug-eluting stents
- Creator
- Rights statement
- Awarding institution
- University of Strathclyde
- Date of award
- 2013
- Thesis identifier
- T13669
- Qualification Level
- Qualification Name
- Department, School or Faculty
- Abstract
- Coronary artery disease is one of the most predominant types of heart diseases present in the 21st century, attributing to a staggering 7.2 million deaths annually across the globe. After implantation of currently the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This battling and persistent problem is of complex aetiology, even with the incorporation of anti-proliferative drugs. One of the key flaws resulting in the restenosis is denying the arterial wall time to heal after implantation due to the sequential drug release. Introducing a novel smart drug delivery system onto stents can enable the release of drug locally in a controlled manner by means of an external ultrasonic stimulus. This ultrasonic-triggered drug release can be tailored to the needs of individuals and controlled within the hands of the cardiologist, to maximise drug efficacy and patient outcome.
- Resource Type
- Note
- This thesis was previously held under moratorium from 17th March 2014 until 17th March 2018.
- DOI
- Date Created
- 2013
- Former identifier
- 9910051853402996
Relations
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PDF of thesis T13669 | 2021-07-02 | Public | Download |