Thesis

Application of X-ray scattering techniques for the analysis of pharmaceutically relevant materials

Downloadable Content

Download PDF
Creator
Rights statement
Awarding institution
  • University of Strathclyde
Date of award
  • 2022
Thesis identifier
  • T16644
Person Identifier (Local)
  • 201776664
Qualification Level
Qualification Name
Department, School or Faculty
Abstract
  • Due to increasing numbers of new chemical entities (NCE) being produced with poor aqueous solubility, there has been an increase in the use of amorphous pharmaceuticals. The research presented within this thesis reports the use of wide angle X-ray scattering (WAXS) as an analysis tool for the characterisation of amorphous solid dispersions (ASDs) to predict the stability of the amorphous form during dissolution. The processing of the ASD was investigated to understand the importance of the processing temperature and the drug loading for paracetamol and affinisol dispersions. Creation of a bespoke sample stage allowed for real-time data of the crystallisation event occurring due to the presence of dissolution media. Investigations of GSK2838232M samples, using small angle X-ray scattering (SAXS), containing various levels of amorphous content showed that with increased milling time, the intensity of the SAXS profile differed which gave insight into the heterogeneity of the samples. SAXS was found to be sensitive to small changes in amorphous content within the milled samples. Cellulose-containing fibres and films were analysed using WAXS. This enabled information on the crystallinity and orientation of cellulose nanocrystals (CNC) within the fibres and films to be extracted. The impact of post-processing of fibres was studied regarding CNC orientation, and this work demonstrated a low-cost method of improving the properties of the material.
Advisor / supervisor
  • Florence, Alastair
  • Robertson, John
Resource Type
Note
  • Previously held under moratorium from 15th June 2023 until 15th June 2025.
DOI

Relations

Items

Thumbnail Title Date Uploaded Visibility Actions
file details PDF of thesis T16644 2023-08-23 Public Download