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GlaxoSmithKline
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Development and understanding of rhodium-catalysed conjugate arylation for process chemistry applications
Creator:
Lovelock, Stephen
Date:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Expanding the scope of asymmetric redox-relay oxidative Heck transformations
Creator:
Bonfield, Holly E.
Date:
2022
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Exploiting DNA-encoded library : technology for the discovery of novel antibody recruiting molecules against LOX-1
Creator:
Macfarlane, Katherine F.
Date:
2022
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Synthesis and biological evaluation of novel small molecule bromodomain inhibitors
Creator:
Stafford, Kayleigh
Date:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Catalytic methods for etherification reactions
Creator:
Whitaker, Luke
Date:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigating streptomyces clavuligerus linear replicons for improved clavulanic acid production
Creator:
Mohit, Elmira
Date:
2023 and 2024
Funder:
Biotechnology and Biological Sciences Research Council
,
GlaxoSmithKline
, and
Industrial Biotechnology Innovation Centre
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Synthetic approaches to heterocyclic systems of pharmaceutical relevance
Creator:
Green, Luke
Date:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Early application of mechanistic PKPD modelling to guide the preclinical development of a therapeutic mAb targeting complement receptor 2 (CR2/CD21) as a novel target for the treatment of autoimmune disease
Creator:
Hooper-Greenhill, Edward
Date:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Homogeneous hydrogenation and photochemistry as tools in pharmaceutical process development
Creator:
Shaalan, Youssef
Date:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of lysine acylating small molecules for covalent kinase inhibition
Creator:
Fournier, Julie C. L.
Date:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel heterocyclic ligands for the lipid kinase PI4KIIIβ : a chemical biology approach
Creator:
Cosgrove, Brett
Date:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
A medicinal chemistry approach towards brodomain epigenetic modulators
Creator:
Law, Robert Peter
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
Creator:
Diallo, Hawa
Date:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The development and evaluation of a method for the quantitative determination of a monoclonal antibody using capillary electrophoresis-high resolution mass spectrometry
Creator:
Snell, Richard
Date:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The use of structure-based drug design to optimise protein-ligand interactions
Creator:
Bertrand, Sophie
Date:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of αvβ6 antagonists as potential idiopathic pulmonary fibrosis agents
Creator:
Anderson, Niall A.
Date:
2013
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Electrochemically enabled synthesis of substituted isoxazolines
Creator:
Holman, Samuel David Lee
Date:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
αV integrin antagonists for the treatment of idiopathic pulmonary fibrosis
Creator:
Thompson, James
Date:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Application of electrochemical based sensors in support of toxicokinetic and pharmacokinetics
Creator:
Mahammed, Farjana
Date:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
Creator:
Fallon, David
Date:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New methods for the synthesis of pharmaceutical azacycles
Creator:
Clark, Peter
Date:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New hydrogen atom transfer methodologies for synthesis
Creator:
Turner, Oliver
Date:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Understanding the hepatic disposition of statins to improve predictions of safety and efficacy
Creator:
Heslop, Teresa Louise
Date:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
Creator:
Shah, Rishi R.
Date:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Application of bioisosteres to modulate molecular properties in medicinal chemistry
Creator:
Measom, Nicholas
Date:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
Creator:
Priestner, John C.
Date:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of chemical probes for non-BET bromodomains
Creator:
Clegg, Michael A.
Date:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The use of contemporary chemoproteomic techniques in antimalarial target identification
Creator:
Tucker, Jessie S.
Date:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New route investigation and process development in the synthesis of GSK221149
Creator:
Roberts, Alastair
Date:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of targeted BET inhibitors
Creator:
Robertson, Craig Michael
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel C-C bond formation strategies for access to secondary and tertiary amides enabled by new synthetic technologies
Creator:
Williams, Jason D.
Date:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel approaches targeting phosphoinositide 3-kinase delta
Creator:
Spencer, Jonathan Andrew
Date:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Synthesis of non-natural base-pairs : towards site-specific functionalisation of nucleic acids
Creator:
Buchanan, Helena Stubbe
Date:
2021 and 2020
Funder:
GlaxoSmithKline
and
EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis
Department, School or Faculty:
Department of Pure and Applied Chemistry
Preclinical development of a treatment for systemic lupus erythematosus
Creator:
Murray, Erin
Date:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of small molecule splice-switchers as inducers of apoptosis
Creator:
Campbell, Emma
Date:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
Creator:
Slack, Robert J.
Date:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
Creator:
Lacroix, Yannick
Date:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of novel epigenetic modulators
Creator:
Jones, Katherine
Date:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of chemical probes for non-BET bromodomains
Creator:
Theodoulou, Natalie
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New dose estimation methods and their application in early drug discovery using intravenous, oral and inhaled routes of administration for new chemical entities
Creator:
Teague, Simon Peter
Date:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
Creator:
Wellaway, Christopher Roland
Date:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The development of chemo- and regioselective reactions of boron systems
Creator:
Clohessy, Thomas A.
Date:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New chemical approaches for the development of targeted protein degradation
Creator:
Lithgow, Hannah
Date:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Targeted protein degradation as a new approach to drug discovery
Creator:
Tinworth, Christopher Patrick
Date:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
Creator:
Hyslop, Julia
Date:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of lysine-targeted irreversible inhibitors of PI3Kδ
Creator:
Dalton, Samuel E.
Date:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases
Creator:
Tame, Christopher J.
Date:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel PI3Kδ inhibitors for the treatment of inflammatory diseases
Creator:
Taylor, Jonathan Andrew
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
Creator:
White, Gemma Victoria
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Studies towards the synthesis and labelling of bioactive peptides
Creator:
Stewart, Sam
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
Creator:
Hayhow, Thomas G.
Date:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development towards prospective modelling of in vivo rabbit QTc prolongation
Creator:
Lewis, Gareth John
Date:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Chan-Lam animation studies : solving the chemotype reactivity issue
Creator:
Vantourout, Julien
Date:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Chemoselective C-H functionalisation of aliphatic azacycles : utilisation of electrophilic iodine as a mild oxidant
Creator:
Griffiths, Robert Joseph
Date:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
Creator:
Summers, Declan M.
Date:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
Creator:
Baker, Blake Jamie Mark
Date:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
Creator:
Sanderson, James
Date:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Computational modelling of enzyme activity to speed up biocatalyst redesign
Creator:
Dréanic, Marie-Pierre
Date:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Increasing the saturation of BET inhibitors
Creator:
Dixon, Joseph Edward
Date:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
Creator:
Wood, Susanna Helen
Date:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
Creator:
Campbell-Crawford, Matthew H. J.
Date:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of small molecule bromodomain inhibitors
Creator:
Lucas, Simon Christopher Cranko Alcock
Date:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
Creator:
Barrett, Victoria J.
Date:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigating and exploiting best practices in hit identification and hit to lead chemistry
Creator:
Borthwick, Jennifer
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Structure-guided approaches to the design of novel autotaxin inhibitors
Creator:
Potjewyd, Frances
Date:
2016
Funder:
Engineering and Physical Sciences Research Council
and
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
Creator:
Tape, Daniel Terence
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
Creator:
Colleville, Aymeric Pierre
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
Creator:
Hardy, Charlotte
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
Creator:
Hobbs, Michael
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Single electron transfer in organic synthesis targeted towards sustainable manufacture
Creator:
Barham, Joshua Philip
Date:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of CCR4 antagonists for the treatment of asthma
Creator:
Miah, Afjal Hussain
Date:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Approaches to lead generation for idiopathic pulmonary fibrosis targets
Creator:
Duffy, Emma
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New methods for the construction of selectively difluorinated carbocycles
Creator:
McCarter, Adam William
Date:
2018
Funder:
GlaxoSmithKline
and
Carnegie Trust for the Universities of Scotland
Department, School or Faculty:
Department of Pure and Applied Chemistry
Automated, quantitative process analysis by NMR
Creator:
Watson, Simon Andrew
Date:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of epigenetic mechanism inhibitors
Creator:
Campbell, Matthew
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Utilisation of rearrangement chemistry in the synthesis of novel fluorinated ring systems : a computational and experimental study
Creator:
Orr, David George Alexander
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
Creator:
Campos, Sébastien André
Date:
2013
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New treatments for inflammatory diseases : optimisation and understanding of key processes
Creator:
Davies, Suzanne H.
Date:
2012
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry and WestCHEM
The development of small molecule inhibitors for fibrosis drug discovery
Creator:
Miller, Lisa Margaret
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of novel inhibitors of carbohydrate-processing targets involved in Mycobacterium tuberculosis cell wall biosynthesis
Creator:
Whitehurst, Ben
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Effects of OGG1 activation on mitochondrial function in response to oxidative stress
Creator:
Katchur, Steven R.
Date:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Mechanistic pharmacokinetic / pharmacodynamic modelling of acute inflammatory challenge models
Creator:
Willis, Robert
Date:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Studies and improvement of molecular docking methods in rigid and flexible receptors
Creator:
Le Gall, Armelle
Date:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of kinase inhibitors as potential anti-inflammatory agents
Creator:
Harrison, Zoë A.
Date:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of the C-methyltransferases NovO and CouO for biocatalytic Friedel-Crafts alkylation
Creator:
Sadler, Joanna C.
Date:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
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